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Perspective on the Osteoclast

Identifieur interne : 00AA72 ( Main/Exploration ); précédent : 00AA71; suivant : 00AA73

Perspective on the Osteoclast

Auteurs : Frank C. Cackowski [États-Unis] ; G. David Roodman [États-Unis]

Source :

RBID : ISTEX:570CFE4882F69B605E825167C936137776097142

Descripteurs français

English descriptors

Abstract

Abstract:  There have been reports recently that the osteoclast stimulates angiogenesis in vitro. We review the evidence suggesting that the osteoclast directly stimulates angiogenesis, and discuss the feasibility of the hypothesis that the osteoclast can be a proangiogenic cell. Reasons supporting the feasibility of this hypothesis include proangiogenic factors produced by osteoclasts, the angiogenic effects of macrophages, the antiangiogenic effects of nitrogen containing bisphosphonates, and the physical proximity of osteoclasts to endothelial cells.

Url:
DOI: 10.1196/annals.1402.073


Affiliations:


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Le document en format XML

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<term>Antiangiogenic</term>
<term>Antiangiogenic effects</term>
<term>Bfgf</term>
<term>Biol</term>
<term>Bisphosphonates</term>
<term>Bone cells</term>
<term>Bone development</term>
<term>Bone matrix</term>
<term>Bone metastases</term>
<term>Bone miner</term>
<term>Bone resorption</term>
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<term>Cackowski roodman</term>
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<term>Cell types</term>
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<term>Clin</term>
<term>Cortical bone</term>
<term>Cytokine</term>
<term>Endochondral ossification</term>
<term>Endothelial</term>
<term>Endothelial cells</term>
<term>Fracture</term>
<term>Fracture healing</term>
<term>Gene expression</term>
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<term>Growth factors</term>
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<term>Myeloma</term>
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<term>Angiogenic activity</term>
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<term>Cytokine</term>
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<term>Endothelial cells</term>
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<term>Fracture healing</term>
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<term>Growth factors</term>
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<term>Miner</term>
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<term>Myeloma cells</term>
<term>Neutralizing antibodies</term>
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<term>Osteoclastogenesis</term>
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<div type="abstract">Abstract:  There have been reports recently that the osteoclast stimulates angiogenesis in vitro. We review the evidence suggesting that the osteoclast directly stimulates angiogenesis, and discuss the feasibility of the hypothesis that the osteoclast can be a proangiogenic cell. Reasons supporting the feasibility of this hypothesis include proangiogenic factors produced by osteoclasts, the angiogenic effects of macrophages, the antiangiogenic effects of nitrogen containing bisphosphonates, and the physical proximity of osteoclasts to endothelial cells.</div>
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